程斌 男 研究员 深圳职业技术大学
电子邮件：chengbin@szpu.edu.cn
通信地址： 广东省深圳市南山区深圳职业技术大学留仙洞校区知行园B座401
研究领域
天然产物全合成；电化学合成；光化学合成
招生信息
博士
招生领域（一级学科）
化学
研究方向
有机化学
教育背景
2004-09~2016-06 中国科学技术大学，有机化学，理学博士
2000-09~2004-06 淮北师范大学，化学教育，理学学士
工作经历
2019-08~至今，深圳职业技术大学，研究员
2012-05~2019-07，兰州大学，副教授
2009-05~2012-04，上海有机化学研究所，助理研究员
专利与奖励
专利成果
（1）螺吲唑氧化吲哚及其制备方法, 发明,2018, 专利号: ZL201710097735.4
（2） 3氢-1,2-二硫代2,2-二氧化物及其制备方法, 发明,2021, 专利号: ZL202010285458.1
（3） 3，4-二氢-2H-1.3-噻嗪类衍生物及其制备方法,发明, 2022, 专利号: ZL202010680873.7
（4）Z-2-(2-酰基亚甲基)噻唑烷-4-酮类衍生物及其制备方法和应用, 发明,2022, 专利号: ZL202110410331.2
（5）三取代吲嗪类化合物及其制备方法,发明, 2022, 专利号: ZL202010285519.4
（6）一种萘并氧硫杂卓类衍生物的制备方法,发明, 2023, 专利号: ZL202210484931.8
出版信息
发表论文
2023
1.Synthesis of 4-(Trifluoromethyl)-2,3-Dihydrothiazoles from α-Enolic Dithioesters and Imidoyl Sulfoxonium Ylides, Dezhi Yang,* Yan Wang, Taimin Wang, Qian Dou,* Kang Zhou, Hongbin Zhai, andBin Cheng*Adv. Synth. Catal.2023,365, 88–95.
2.From benzopyrroles to phenylpyrroles: remodeling of indoles enabled by photoredox catalysis, Wei Xu,Bin Cheng,* Yaoge Zhang, Lijing Fang, Hongbin Zhai, Cuiping Wang* and Taimin Wang*Org. Chem. Front.2023,10, 3875–3882.
3.Access to Chromenopyrrolidines Enabled by Organophotocatalyzed [2 + 2 + 1] Annulation of Chromones with N‑Arylglycines, Xin Zhou, Biwei Zhang, Ping Wu, Wei Xu, Renqi Wang,* Jingbai Li, Hongbin Zhai,Bin Cheng,* and Taimin Wang*Org. Lett.2023,25, 7512−7517.
4.Recent Development of Photoinduced Iron-Catalysis in Organic Synthesis, Dou, Qian, Wang, Taimin,* Fang, Lijing, Zhai, Hongbin,Cheng, Bin,*Chin. J. Org. Chem.2023,43, 1386−1415 (Review).
5.Visible Light-Induced Pd-Catalyzed Heck Reactions, Xu, Wei, Zhai, Hongbin,*Cheng, Bin,* Wang, Taimin,*Chin. J. Org. Chem.2023,43, 3035−3054 (Review).
6.Copper-Catalyzed Enantioconvergent Radical C(sp3)−N Cross-Coupling of Activated Racemic Alkyl Halides with (Hetero)aromatic Amines under Ambient Conditions, Ji-Jun Chen, Jia-Yong Zhang, Jia-Heng Fang, Xuan-Yi Du, Hai-Dong Xia,Bin Cheng, Nan Li, Zhang-Long Yu, Jun-Qian Bian, Fu-Li Wang, Jing-Jing Zheng, Wei-Long Liu, Qiang-Shuai Gu, Zhong-Liang Li, and Xin-Yuan Liu*J. Am. Chem. Soc.2023,145, 14686−14696.
7.Catalyst-free inverse-electron-demand aza-Diels–Alder reaction of 4,4-dicyano-2-methylenebut-3-enoates and 1,3,5-triazinanes: access to polysubstituted tetrahydropyridines, Dezhi Yang,* Meng Zhu, Taimin Wang, Yixuan He, Lang Xie, Jiayong Zhang* andBin Cheng*,Org. Biomol. Chem.2023,21, 5413–5418.
8.A decade update on the application of β-oxodithioesters in heterocyclic synthesis, Zhi-Bing Dong,* Zhiying Gong, Qian Dou,Bin Cheng* and Taimin Wang*,Org. Biomol. Chem.2023,21, 6806–6829.
9.Synthesis of Spiro[benzofuran-2,3′-pyrazol]-3-imines from Aurone-Derived Azadienes and Hydrazonoyl Chlorides via Regioand Diastereospecific [2+3] Cycloaddition, Dilnigar Askar, Xiancheng Liu, Ablikim Obolda,* Wei Xu,* Yan Xu, Guixue Wang, Taimin Wang, Hongbin Zhai,Bin Cheng*Synthesis2023,55, 1561–1569.
10.Recent advances in phosphorylation of hetero-nucleophilic reagents via P-H bond cleavage, Sifeng Li, Lijing Fang,* Qian Dou, Taimin Wang,*Bin Cheng,*Tetrahedron2023,136, 133344（Review）.
2022
11.Synthesis of Chromeno[2,3‑d]pyrimidin-5-one Derivatives from 1,3,5-Triazinanes via Two Different Reaction Pathways, Taimin Wang,* Biwei Zhang, Lin Hu,* Haiyan Sun, Yan Wang, Hongbin Zhai, andBin Cheng,*J. Org. Chem.2022,87, 1348−1356.
12.Electrochemical Decarboxylative Coupling of N-Substituted Glycines under Air: Access to C3-Aminomethylated Imidazo[1,2-a]pyridines, Sifeng Li, Xingchen Li, Taimin Wang,* Qingjing Yang, Zijun Ouyang, Jieyu Chen, Hongbin Zhai, Xiao Li,* andBin Cheng,*Adv. Synth. Catal.2022,364, 2346–2351.
13.Synthesis of aryl-fused 1,4-oxathiepines from pyridinium 1,4-zwitterionic thiolates and vinylidene ortho-quinone methides, Yixuan He, Ping Wu, Xiang Zhang, Taimin Wang,* Qingqing Tao, Kang Zhou, Zijun Ouyang, Hongbin Zhai, Dao-Juan Cheng* andBin Cheng,*Org. Chem. Front.2022,9, 4612–4618.
14.Concise total synthesis of (±)-pileamartines A and B, Wei Xu, Taimin Wang,* Xin Zhou, Lijing Fang, Chen Zhang, Hongbin Zhai* andBin Cheng,*Org. Chem. Front.2022, 9, 6968–6972.
15.Switchable electrooxidative N-methyl amines: access to C3-aminomethylated and C3-arylmethylated imidazo[1,2-a] pyridines, Sifeng Li,* Taimin Wang,* Xingchen Li, Lijing Fang, Hongbin Zhai andBin Cheng,*Green Chem.2022,24, 9482–9488.
16.Recent advances in photochemical construction of aromatic C–P bonds via C–hetero bond Cleavage, Qian Dou, Taimin Wang,Bin Cheng,* Chao-Jun Li and Huiying Zeng,*Org. Biomol. Chem.2022,20, 8818–8832 (Review).
17.Recent Advances in Photocatalytic Carboxylation with CO2 via σ-Bond Cleavage, Qian Dou, Taimin Wang*, Sifeng Li, Lijing Fang, Hongbin Zhai,Bin Cheng,*Chin. J. Org. Chem.2022,42, 4257–4274 (Review).
18.The applications of electrochemical synthesis in asymmetric catalysis, Ke-Jin Jiao, Zhen-Hua Wang, Cong Ma,* Hui-Lin Liu,Bin Cheng,* and Tian-Sheng Mei,*Chem. Catalysis2022,2, 3019–3047 (Review).
2021
19.Synthesis of Hydrobenzoimidazoles from para-Quinamines and 1,3,5-Triazinanes via a Formal [3+2] Annulation Reaction, Xinping Zhang,Bin Cheng,* Hui Li, Yixuan He, Wei Xu, Xiaoguang Duan, Haiyan Sun, Taimin Wang,* and Hongbin Zhai,*Adv. Synth. Catal.2021,363, 565–569.
20.Photoinduced transition-metal and external photosensitizer free cross-coupling of aryl triflates with trialkyl phosphites, Qian Dou, Li Geng,Bin Cheng,* Chao-Jun Li,* and Huiying Zeng,*Chem. Commun.2021,57, 8429–8432.
21.Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids, Ke-Jin Jiao, Cong Ma, Dong Liu, Hui Qiu,Bin Cheng,* and Tian-Sheng Mei,*Org. Chem. Front.2021,8, 6603–6608.
22.Diversity-oriented synthesis of benzofuro[3,2-b]pyridine derivatives from aurone-derived α,β-unsaturated imines and activated terminal alkynes,Bin Cheng,* Hui Li, Xuecheng Zhu, Xinping Zhang, Yixuan He, Haiyan Sun, Taimin Wang,* and Hongbin Zhai,*Chem. Commun.2021,57, 7701–7704.
23.Synthesis of tetrasubstituted thiophenes from pyridinium 1,4-zwitterionic thiolates and modified activated alkynes, Taimin Wang,* Xuecheng Zhu, Qingqing Tao, Wei Xu, Haiyan Sun, Ping Wu,Bin Cheng,* Hongbin Zhai,*Chin. Chem. Lett.2021,32, 3972–3975.
24.Synthesis of 5H‑Chromeno[2,3‑d]pyrimidin-5-one Derivatives via Microwave-Promoted Multicomponent Reaction, Biwei Zhang, Hongjian Yang, Taimin Wang,* Xuanzhen Han, Haiyan Sun, Lijing Fang, Hongbin Zhai,* andBin Cheng,*J. Org. Chem.2021,86, 18304−18311.
25.Synthesis of 1,3,4-Thiadiazoles and 1,4,2-Oxathiazoles from α‑Enolic Dithioesters and Active 1,3-Dipoles,Bin Cheng,* Hui Li, Jianguo Sun, Xinping Zhang, Yixuan He, Haiyan Sun, Wei Xu, Taimin Wang,*and Hongbin Zhai,*J. Org. Chem.2021,86, 5265−5273.
26.Synthesis of thiazolidin-4-ones from α-enolic dithioesters and a-halohydroxamates, Jianguo Sun, Taimin Wang, Xuecheng Zhu, Wei Xu,*Bin Cheng,* and Hongbin Zhai*,New J. Chem.2021,45, 14508–14512.
27.Synthesis of Spiro[indazole-3,3’-indolin]-2’-ones and Indazolo[2,3-c]quinazolin-6(5H)-ones from Arynes and Isatin-Derived N-Tosylhydrazones,Bin Cheng,* Yixuan He, Xinping Zhang, Hui Li, Zijie Ding, Lizhe Feng, Haiyan Sun, Taimin Wang,* Hongbin Zhai,*Synthesis2021,53, 3578–3584.
28.Synthesis of pyrazolotetrazepin-7-ones from 1,3,5-triazinanes with N,N’-cyclic azomethine imines via a formal (5 + 2) pathway,Bin Cheng,* Yixuan He, Hongjian Yang, Hui Li, Xinping Zhang, Wei Xu, Haiyan Sun, Taimin Wang,* Hongbin Zhai,*Tetrahedron2021,89, 132130.
2020
29.14.4.14 2H-1-Benzopyran-2-ones,Cheng, B.; Wang, T.; Science of Synthesis Knowledge Updates, (2020) 3, 141. DOI 10.1055/sos-SD-114-00353.
30.14.4.15 2H-1-Benzopyran-2-thiones,Cheng, B.; Wang, T.; Science of Synthesis Knowledge Updates, (2020) 3, 233. DOI 10.1055/sos-SD-114-00473.
31.Two Reaction Modes of Pyridinium 1,4-Zwitterionic Thiolates with Sulfenes: Synthesis of 3H‑1,2-Dithiole 2,2-Dioxides, 1,9a- Dihydropyrido[2,1‑c][1,4]thiazines, and Indolizines,Cheng, B.*;Li, Y.; Zhang, X.; Duan, S.; Li, H.; He, Y.; Li, Y.; Wang, T.*; Zhai, H.*Org. Lett.2020, 22, 5817–5821.
32.Synthesis of indolizines from pyridinium 1,4-zwitterionic thiolates and α-functionalized bromoalkanes via a stepwise [(5 + 1)−1] pathway,Cheng, B.*; Zhang, X.; Li, Y.; Li, H.; He, Y.; Li, Y.; Wang, T.*; Zhai, H.*Chem. Commun.2020, 56, 8396–8399.
33.Synthesis of tetrasubstituted thiophenes via a [3+2] cascade cyclization reaction of pyridinium 1,4-zwitterionic thiolates and activated allenes, Zhai, S.; Zhang, X.;Cheng, B.*; Li, H.; Li, Y.; He, Y.; Li, Y.; Wang, T.*; Zhai, H.*,Chem. Commun.2020,56, 3085–3088.
34.Synthesis of 1,2,3,4-Tetrahydrobenzofuro[3,2-d]pyrimidines via [4+2] Annulation Reaction of 1,3,5-Triazinanes and Aurone-Derived α,β-Unsaturated Imines,Cheng, B.*;Zhang, X.; Zhai, S.; He, Y.; Tao, Q.; Li, H.; Wei, J.; Sun, H.; Wang, T.*; Zhai, H.*Adv. Synth. Catal.2020,362, 3836−3840.
35.Synthesis of Pyridothiazepines via a 1,5-Dipolar Cycloaddition Reaction between Pyridinium 1,4-Zwitterionic Thiolates and Activated Allenes,Cheng, B.*;Zhang, X.; Li, H.; He, Y.; Li, Y.; Sun, H.; Wang, T.*; Zhai, H.*Adv. Synth. Catal.2020,362, 4668−4672.
36.Application of Pyridinium 1,4-Zwitterionic Thiolates: Synthesis of Benzopyridothiazepines and Benzothiophenes,Cheng, B.*;Li, Y.; Wang, T.; Zhang, X.; Li, H.; He, Y.; Li, Y.; Zhai, H.*J. Org. Chem.2020,85, 6794−6802.
37.Synthesis of 3,4-Dihydro-2H-1,3-thiazines from α-Enolic Dithioesters and 1,3,5-Triazinanes via a Formal (3 + 3) Annulation Reaction,Cheng, B.*;Li, H.; Hou, J.; Zhang, X.; He, Y.; Sun, H.; Xu, W.; Wang, T.*; Zhai, H.*J. Org. Chem.2020,85, 13339−13346.
38.Switchable Ring-Contractive Extrusion Reactions of 2,5-Dihydro-1,4,5-thiadiazepine S‑Oxides: Entries to Pyridazines or Pyrazoles,Cheng, B.*; Li, Y.; Li, H.; Zhang, X.; Wang, T.; Li, Y.; Zhai, H.*,J. Org. Chem.2020,85, 1109–1114.
39.Synthesis of indolizines from pyridinium 1,4-zwitterionic thiolates and propiolic acid derivatives via a formal [4 + 1] pathway,Cheng, B.*;Li, H.; Duan, S.; Zhang, X.; He, Y.; Li, Y.; Li, Y.; Wang, T.*; Zhai, H.*Org. Biomol. Chem.2020,18, 6253−6257.
40.Synthesis of fully substituted pyrazoles from pyridinium 1,4-zwitterionic thiolates and hydrazonoyl chlorides via [[3+3]-1] pathway,Cheng, B.*; Bao, B.; Xu, W.; Li, Y.; Li, H.; Zhang, X.; Li, Y.; Wang, T.*; Zhai, H.*Org. Biomol. Chem.2020, 18, 2949–2955
41.Development and Application of Pyridinium 1,4-Zwitterionic Thiolates: Synthesis of Polysubstituted Thiophenes,Cheng, B.*; Duan, X.; Li, Y.; Zhang, X.; Li, H.; Wu, F.; Li, Y.; Wang, T.*; Zhai, H.*,Eur. J. Org. Chem.,2020,2020, 1896–1906.
2019
42.Syntheses of spiro[indazole-3,3’-indolin]-2’-ones and spiro[indazole-3,3’-indolin]-2’-imines via 1,3-dipolar cycloadditions of arynes and studies on their isomerization reactions,Cheng, B.*; Li, Y.; Zu, B.; Wang, T.; Wang, R.; Li, Y.; Zhai, H.*,Tetrahedron,2019,75, 130775.
43.Pyridinium 1,4-zwitterionic thiolates as a useful class of sulfur-containing synthons: application to the synthesis of 2,5-dihydro-1,4,5-thiadiazepines,Cheng, B.*; Li, Y.; Wang, T.; Zhang, X.; Li, H.; Li, Y.; Zhai, H.*,Chem. Commun.,2019, 55, 14606–14608.
发表著作
1.Science of Synthesis Knowledge Updates 2020/3, 14.4.14 2H-1-Benzopyran-2-ones & 14.4.15 2H-1-Benzopyran-2-thiones ISSN (print) 2510-5469, ISSN (online) 2566-7297 2021德国Thieme出版社
科研活动
科研项目
1.“Lapidilectine类蕊木生物碱的合成研究”，项目号：21472072，执行年限：2015.01–2018.12，国家自然科学基金委资助的面上项目（主持）。
2.“一类新颖的硫内盐在杂环合成中的应用”，项目号：21971092，执行年限：2020.01–2023.12，国家自然科学基金委资助的面上项目（主持）。
3.“石松子生物碱Lycoposerramine S的合成研究”，项目号：21302077，执行年限：2014.01–2017.12，国家自然科学基金委资助的青年基金项目（主持）。
4.“荧光标记脱氧核糖核苷酸技术研发”，项目号：GJHZ20200731095412037，执行年限：2021.07–2023.06，深圳市科技创新委员会资助的国际合作项目（主持）。
5.“重2020N045高效液相离子交换分离血红蛋白层析柱关键技术研发合同”，项目号：JSGG20201103153800002，执行年限：2021.04–2024.04，深圳市科技创新委员会资助的技术攻关重点项目（作为合作单位参与）。
6.“海洋药源小分子研究与开发创新团队”，项目号：508-6022240003T，执行年限：2022/07-2025/06，广东省教育厅（主持）
7.“深圳市海洋活性物质工程研究中心”项目号：508-6022210010P，执行年限：2022/01-2024/12，深圳市发展和改革委员会（主持）
8.“雌二醇和孕酮特定衍生物的定制合成”，项目号：6021260233K，执行年限：2021/03-2022/03，深圳普门科技股份有限公司，横向项目，（主持）
9.Dapagliflozin, Canagliflozin, Remdesivir等医药中间体小试工艺路线技术开发，项目号：6022260231K，执行年限：2022/09-2025/08，合肥欧创基因生物科技有限公司，横向项目，（主持）
指导学生
已指导学生
李 慧 硕士研究生 070303-有机化学
张昕平 硕士研究生 070303-有机化学
贺一轩 硕士研究生 070303-有机化学
周 鑫 硕士研究生 070303-有机化学
王 岩 硕士研究生 070303-有机化学
李兴宸 硕士研究生 070303-有机化学
迪丽妮尕尔·艾斯卡尔 硕士研究生 070303-有机化学
方程程 硕士研究生 070303-有机化学
焦科进 博士后 070303-有机化学
窦 谦 博士后 070303-有机化学
徐 伟 博士后 070303-有机化学
张甲勇 博士后 070303-有机化学
高纪罡 博士后 070303-有机化学
